Pfam 15.0 (Saint Louis)
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Pfam HMM search results, glocal+local alignments merged (Pfam_ls+Pfam_fs)

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Model Seq-from Seq-to HMM-from HMM-to Score E-value Alignment Description
!! Trypsin 106281125967.82.9e-17glocalTrypsin
!! PDZ 28337218233.46.8e-07glocalPDZ domain (Also known as DHR or GLGF)
!! PDZ 39147118217.40.0065glocalPDZ domain (Also known as DHR or GLGF)

Trypsi PDZ domain (Also known as DHR or GLGF PDZ domain (Also known as DHR or GLGF




   Alignments of top-scoring domains:

Format for alignment of query to Seed: 
Trypsin: domain 1 of 1, from 106 to 281: score 67.8, E = 2.9e-17
                   *->IvGGeeaqpgsfgsPwqvslqvrsgggsgkhfCGGsLisen..wVLT
                          ++a+p ++      s+q  ++         G++i+e +++++T
        htrA   106    ----DDAAPAEH------SFQSAGS---------GVVIDEVhgYIVT 133  

                   AaHCvsgsasakassvrVSlslrlGehnlvltegteqkfdvkktiivHpn
                   + H++ +     as+++V     l++   +++++     +  +       
        htrA   134 NQHVIAS-----ASKIEV----ALSD--GRRFQA-----KLVG------- 160  

                   ynpdtldgeYdnDiALlkLkspgvtlgdtvrpicLpsttassdlpvGttc
                    +p+t       D+A++++ ++      +   + ++s    s+l+vG  +
        htrA   161 ADPET-------DVAVVQIPPD------HLVQAEFGS---ASSLHVG--D 192  

                   tvsGwGrrptknlglpdtLqevvvpvvsretCrssyeyggtdDkiefvtd
                   +v+++G+  ++ lg  +t ++++v++++r  + s     g+        +
        htrA   193 VVVAIGN--PFGLG--QTATMGIVSALGRRAVGSE----GY--------E 226  

                   nmiCagalggkdaCqGDSGGPLvcsdggrgrwelvGivSwGsygCargnk
                   ++i+++a    ++++G+SGG+Lv++dg      +vGi+S++  g+a+g  
        htrA   227 GFIQTDA----STNPGNSGGALVSEDG-----VVVGINSAI-IGPAGGSI 266  

                   .PGvytrVssyldWI<-*
                   ++G++++  ++  +    
        htrA   267 gIGFAVPAETVGIVM    281  


PDZ: domain 1 of 2, from 283 to 372: score 33.4, E = 6.8e-07
                   *->evtlekevkrgglGfsikggsdk...........givvsevlpGsga
                      +++l     rg++G+  +  + +  +  + +++ g+ vsevlpGs+a
        htrA   283    QLILTGKLVRGEVGILTQDLTPGlakafgidegaGALVSEVLPGSPA 329  

                   AeagGrLkeGDvIlsvNGqdvenlsheravlalkgsggsevtLtvl<-*
                   A ag  +++GDvI  v+G+ v++ s+ r      +  + + + ++    
        htrA   330 ANAG--IQPGDVIRMVDGRTVRGASDVRRLVGSLPLQS-KPSFQID    372  


PDZ: domain 2 of 2, from 391 to 471: score 17.4, E = 0.0065
                   *->evtlekevkrgglG.fsikggsdk....givvsevlpGsgaAeagGr
                      e   ++  ++ g G++  +++ + ++++g+ v  v +Gs aA+ag  
        htrA   391    EPAAPRT-IHIGRGpLADAEMANSpdgpGARVVVVAEGSVAAQAG-- 434  

                   LkeGDvIlsvNGqdvenlsheravlalkgsggsevtLtvl<-*
                   L+++DvI++ ++q+v+++ ++  +l+   +      +tv    
        htrA   435 LQPDDVIVALDQQPVTDVGQLLSILVKEHA---RALITVV    471

   NEW! Phylogenomic analysis of query using RIO.

Given a query sequence, Pfam domain, and species, the RIO server will order sequences in the Pfam domain by orthology to the query. Many other options are available, and an annotated gene tree can be generated and viewed with ATV. The button below will send your query and Pfam domain hits to the RIO server.
   


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